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Gambaran Hiperurisemia pada Subyek Keturunan Hipertensi dan Tidak Keturunan Hipertensi Berhandus, Catrien; Ongkowijaya, Jeffrey A.; Kaparang, Adeodata M. C.
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.33044

Abstract: Hypertension is one of the most common cardiovascular diseases worldwide. Hyperuricemia is considered if serum uric acid level >7 mg/dl in men and >6 mg/dl in women. This condition is not only associated with gout but has other associations with various diseases such as cardiovascular disease, systemic inflammation, endothelial dysfunction, and hypertension. This study was aimed to obtain the description of serum uric acid levels among people who had family history of hypertension and those who did not. This was a descriptive and observational study with a cross-sectional design. Samples were obtained at Prof. dr. R. D. Kandou Manado by using consecutive sampling, and then were divided into two groups, with and without family history of hypertension; each of 20 people. Of the group with family history of hypertension, 12 were male (60%) and 8 were female (40%), while of the other group, 10 were male (50%) and 10 were female (50%). Based on serum uric acid levels, 6 (30%) of the group with family history of hypertension had hyperuricemia, while 3 (15%) of the other group had hyperuricemia; all of them were male. In conclusion, people with family history of hypertension had hyperuricemia more frequently compared to those without family history of hypertension, with dominant male sex in both groups.Keywords: uric acid; family history of hypertension; hyperuricemiaÂ Abstrak: Hipertensi masih merupakan salah satu penyakit kardiovaskular yang paling umum di seluruh dunia. Hiperurisemia ditetapkan bila kadar serum asam urat >7 mg/dl pada laki-laki dan >6 mg/dl pada perempuan. Hiperurisemia tidak hanya berhubungan dengan gout tetapi memiliki hubungan dengan berbagai penyakit seperti penyakit kardiovaskular, inflamasi sistemik, disfungsi endotel, dan hipertensi. Penelitian ini bertujuan untuk mendapatkan gambaran asam urat pada subyek keturunan hipertensi dan tidak keturunan hipertensi. Jenis penelitian ialah observasional deskriptif dengan desain potong lintang. Sampel diperoleh di RSUP Prof. Dr. R. D. Kandou Manado menggunakan consecutive sampling dan dibagi atas dua kelompok, yaitu keturunan hipertensi dan tidak keturunan hipertensi dari hasil anamnesis; masing-masing terdiri dari 20 orang. Dari kelompok keturunan hipertensi didapatkan 12 subyek laki-laki (60%) dan 8 perempuan (40%), sedangkan dari kelompok lainnya sebanyak 10 subyek laki-laki (50%) dan 10 subyek perempuan (50%). Berdasarkan kadar asam urat, dari kelompok keturunan hipertensi sebanyak 6 orang (30%) mengalami hiperurisemia, sedangkan pada kelompok lainnya sebanyak 3 orang (15%) mengalami hiperurisemia. Semua subyek pada kedua kelompok yang mengalami hiperurisemia berjenis kelamin laki-laki. Simpulan penelitian ini ialah subyek keturunan hipertensi lebih banyak mengalami hiperurisemia dibandingkan subyek tidak keturunan hipertensi, dengan jenis kelamin laki-laki dominan pada kedua kelompok.Kata kunci: asam urat; keturunan hipertensi; hiperurisemia

Efek Hepatoprotektif Tanaman Obat Palawe, Christesa Y.; Kairupan, Carla F.; Lintong, Poppy M.
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.33542

Abstract: Medicinal plant that contain antioxidants is an alternative therapeutic option for liver disorders. This study was aimed to review the hepatoprotective effects of medicinal plants. This was a literature review study using PubMed, Google Scholar and Clinical Key. The results showed 10 hepatoprotective medicinal plants, as follows: Â soursop leaves, yellow bamboo shoots, moringa leaves, green betel leaves, libo fruit, kenikir, neem leaves, bitter bean seeds, black cumin, and solo garlic. All of them showed hepatoprotective activities based on the results of the tests, using biochemical and histopathological parameters. Soursop leaves could increase SOD level and reduce MDA level; yellow bamboo shoots were demonstrated to maintain SGPT activities and bilirubin level; moringa leaves have been associated with the reduction of MDA, SGOT, and SGPT levels; green betel leaves were able to reduce SGOT and SGPT levels and improve liver centrolobular necrosis; libo fruit was able to lower SGPT level; kenikir and bitter bean seeds were shown to reduce SGOT and SGPT levels; neem leaves were associated with the reduction of ALT level and protection against liver cell damage; black cumin was found to reduce fat degeneration; solo garlic could reduce MDA, SGPT, and SGOT levels, and maintain SOD level. In conclusion, the 10 hepatoprotective medicinal plants have the ability to increase SOD levels, reduce SGOT, SGPT and MDA levels, maintain bilirubin levels, regenerate centrilobular necrosis of the liver, and reduce fat degeneration of the liver. Solo garlic shows the largest amount of hepatoprotective activities, followed by yellow bamboo shoots, green betel leaves and libo fruit.Keywords: medicinal plants, hepatoprotector effectÂ Â Abstrak: Pengobatan menggunakan tanaman obat yang mengandung antioksidan merupakan pilihan terapi alternatif untuk gangguan pada hati. Penelitian ini bertujuan untuk menelaah efek hepatoprotektif tanaman obat. Jenis penelitian ialah literature review dengan menggunakan PubMed, Google Scholar dan Clinical Key. Hasil penelitian mendapatkan 10 tanaman obat hepatoprotektor yaitu daun sirsak, rebung bambu kuning, daun kelor, daun sirih hijau, buah libo, kenikir, daun mimba, biji petai, jintan hitam, dan bawang lanang. Tanaman-tanaman obat tersebut memiliki aktivitas hepatoprotektif berdasarkan pengujian dengan parameter biokimia dan histopatologi. Daun sirsak dapat meningkatkan kadar SOD dan menurunkan kadar MDA; rebung bambu kuning dapat mempertahankan aktivitas SGPT dan kadar bilirubin; daun kelor menurunkan kadar MDA, SGOT, dan SGPT; daun sirih hijau menurunkan kadar SGOT dan SGPT, serta memperbaiki nekrosis sentrolobuler hati; buah libo menurunkan kadar SGPT; kenikir dan biji petai menurunkan kadar SGOT dan SGPT; daun mimba menurunkan kadar SGPT dan memiliki daya proteksi terhadap kerusakan sel hati; jintan hitam dapat mengurangi degenerasi lemak; bawang lanang menekan peningkatan kadar MDA, SGPT, SGOT dan mempertahankan kadar SOD. Simpulan penelitian ini Kesepuluh tanaman obat hepatoprotektor tersebut memiliki kemampuan dalam meningkatkan kadar SOD, menurunkan kadar SGOT, SGPT dan MDA, mempertahankan kadar bilirubin, memperbaiki nekrosis sentrolobuler hati, dan mengurangi degenerasi lemak hati. Bawang lanang menunjukkan aktivitas hepatoprotektor terbesar, diikuti rebung bambu kuning, daun sirih hijau, dan buah libo.Kata kunci: tanaman obat, efek hepatoprotektor

Perilaku Masyarakat Desa terhadap Penyakit Malaria di Masa Pandemi Covid-19 Rading, Fabio B.; Pijoh, Victor D.; Tuda, Josef S. B.
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.33073

Abstract: To date, the number of malaria cases in North Sulawesi is still quite high which may be influenced by community behavior. Kauditan District, especially in Kaima village, is one of the areas in North Minahasa Regency that has the highest incidence of malaria. Moreover, community's behavior has changed greatly during the current Covid-19 pandemic. This study was aimed to determine the behavior of the Kaima village community, Kauditan District, North Minahasa Regency towards malaria during the Covid-19 pandemic. This was a descriptive study. There were 100 people of Kaima village as respondents in this study. The results showed that based on the level of knowledge about malaria, 66 respondents (66%) had good knowledge. Based on the attitudes towards malaria, 95 respondents (95%) had good attitudes. Based on the action against malaria, 61 respondents (61%) had good action. In conclusion, during Covid-19 pandemic, people of Kaima village had good knowledge about the malaria incidence, however, there was lack of knowledge about the types and activities of biting of the mosquitoes. Moreover, people of Kaima village had good attitude and good actions towards malaria incidence, albeit, there are still obstacles in implementing these actions.Keywords: behavior; malaria; Covid-19Â Â Abstrak: Angka kasus malaria di Sulawesi Utara yang masih cukup tinggi mungkin dipengaruhi oleh perilaku masyarakat. Kecamatan Kauditan terlebih khusus di desa Kaima merupakan salah satu daerah di Kabupaten Minahasa Utara yang memiliki angka kejadia malaria tertinggi. Di masa pandemi Covid-19, perilaku masyarakat sudah sangat berubah. Penelitian ini bertujuan untuk mengetahui perilaku masyarakat Desa Kaima Kecamatan Kauditan Kabupaten Minahasa Utara terhadap penyakit malaria di masa pandemi Covid-19. Jenis penelitian ialah deskriptif. Terdapat 100 responden dalam penelitian ini yang merupakan masyarakat Desa Kaima. Hasil penelitian mendapatkan bahwa berdasarkan tingkat pengetahuan terhadap penyakit malaria didapatkan subjek yang berpengetahuan baik sebanyak 66 orang (66%). Berdasarkan sikap terhadap penyakit malaria didapatkan subjek yang mempunyai sikap baik sebanyak 95 orang (95%). Berdasarkan tindakan terhadap penyakit malaria didapatkan subjek yang mempunyai tindakan baik sebanyak 61 orang (61%). Simpulan penelitian ini ialah pada masyarakat Desa Kaima di masa pandemi Covid-19, pengetahuan terhadap kejadian malaria secara keseluruhan sudah baik namun masyarakat masih kurang pengetahuan mengenai jenis dan aktivitas mengigit nyamuk, Sikap masyarakat dan tindakan masyarakat terhadap kejadian malaria sudah baik, namun terdapat kendala dalam pelaksanaan tindakan tersebut.Â Kata kunci: perilaku masyarakat; malaria; pandemi Covid-19

Peran Terlipressin pada Penyakit Hati Kronik Andrea, Decky; Rotty, Luciana
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.33784

Abstract: Chronic liver disease is a progressive impairment of liver function. It is caused by non-alcoholic fatty liver, viral infection of the liver, excessive alcohol consumption, metabolic diseases such as galactosemia, autoimmune disease, and the influence of chemicals. Complications that are often found are esophageal variceal bleeding, hepatorenal syndrome, and refractory ascites. Terlipressin, which is a vasopressin analogue, is currently widely used in developed countries because it has been shown to improve survival of patients with esophageal varices, hepatorenal syndrome, and refractory ascites. Terlipressin is the current standard therapy for esophageal variceal bleeding in countries where it is available.Keywords: chronic liver disease; terlipressinÂ Â Abstrak: Penyakit hati kronis (PHK) adalah gangguan fungsi hati yang terjadi secara progresif. Peyakit hati kronis di sebabkan oleh non-alcoholic fatty liver, infeksi virus pada hati, konsumsi alkohol berlebihan, peyakit metabolik seperti galaktosemia, penyakit autoimun, dan pengaruh bahan kimia. Komplikasi yang sering ditemukan pada PHK ialah perdarahan varises esofagus, sindrom hepatorenal, dan asites refrakter. Terlipressin yang merupakan analog vasopressin saat ini banyak di pakai di negara maju karena terbukti dapat meningkatkan kelangsungan hidup pasien perdarahan varises esofagus, sindrom hepatorenal, dan asites refrakter. Dewasa ini terlipressin telah menjadi terapi standar perdarahan varises esofagus di negara-negara di mana obat ini tersedia.Kata kunci: penyakit hati kronik; terlipressin

Morfologi, Patogenesis, dan Imunoterapi Kanker Paru Tipe Adenokarsinoma Robot, Renita Y.; Durry, Meilany F.; Kairupan, Carla F.
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.33544

Abstract: Although some common therapies for cancers are available, many patients experience relapse during therapy. Therefore, an understanding of the pathogenesis of lung adenocarcinomas is needed in lung cancer therapies, especially targeted therapies. Immunotherapy has been shown to be effective in the therapy of various tumors, including non-small cell lung cancer (NSCLC). This study was aimed to review the morphology, pathogenesis, and immunotherapy of lung adenocarcinomas. This was a literature review study using databases of Clinical Key, Pubmed, and Google Scholar. The results showed that morphology of lung adenocarcinomas was characterized by the presence of lesions consisting of several morphological spectra, starting with pre-invasive lesions, then minimally invasive adenocarcinomas to invasive adenocarcinomas. Pathogenesis of lung adenocarcinomas was associated with genetic changes of several genes such as EGFR, KRAS, ALK, and ROS1; however, the most frequently involved were EGFR, KRAS, and ALK. The immunotherapies used for lung adeno-carcinomas were nivolumab, pembrolizumab, atezolizumab, tremelimumab, durvalumab, avelumab, cemiplimab, cetuximab, panitumumab, and matuzumab; however, the most commonly used were nivolumab, pembrolizumab, and atezolizumab. In conclusion, morphological spectra of lung adeno-carcinomas are pre-invasive lesions, minimally invasive adenocarcinomas, and invasive adeno-carcinomas. Pathogenesis of lung adenocarcinomas is associated with the presence of genetic changes, especially mutations of EGFR, KRAS and ALK. The most widely used immunotherapies for lung adenocarcinomas are nivolumab and pembrolizumab, which are included in the PD-1 antibody group and atezolizumab in the PD-L1 antibody group.Keywords: lung adenocarcinoma morphology; pathogenesis; immunotherapyÂ Â Abstrak: Telah tersedia beberapa terapi umum kanker namun banyak pasien mengalami kekambuhan saat terapi. Oleh karena itu dibutuhkan pemahaman tentang patogenesis adenokarsinoma paru dalam terapi kanker paru khususnya terapi target. Imunoterapi dianggap sebagai teknologi yang memberikan harapan dan telah terbukti efektif dalam terapi berbagai tumor, termasuk non-small cell lung cancer (NSCLC). Penelitian ini bertujuan untuk menelaah morfologi, patogenesis, dan imunoterapi dari kanker paru tipe adenokarsinoma. Jenis penelitian ialah literature review menggunakan database Clinical Key, Pubmed, dan Google Scholar. Hasil penelitian mendapatkan morfologi adenokarsinoma paru ditandai adanya lesi yang terdiri dari beberapa spektrum morfologik, diawali dengan lesi preinvasif, selanjutnya lesi adenokarsinoma invasif minimal sampai adenokarsinoma invasif. Patogenesis adenokarsinoma paru berhubungan dengan perubahan genetik beberapa gen, yaitu EGFR, KRAS, ALK, dan ROS1; namun yang paling sering terlibat ialah EGFR, KRAS, dan ALK Imunoterapi yang digunakan untuk terapi adenokarsinoma paru ialah nivolumab, pembrolizumab, atezolizumab, tremelimumab, durvalumab, avelumab, cemiplimab, cetuximab, panitumumab, dan matuzumab; namun terbanyak digunakan ialah nivolumab, pembrolizumab, dan atezolizumab. Simpulan penelitian ini ialah spektrum morfologi dari adenokarsinoma paru berupa lesi preinvasif, adenokarsinoma invasif minimal, dan adenokarsinoma invasif. Patogenesis dari adenokarsinoma paru berhubungan dengan adanya perubahan genetik, terutama mutasi EGFR, KRAS, dan ALK. Imunoterapi yang paling banyak digunakan untuk terapi adenokarsinoma paru ialah nivolumab dan pembrolizumab yang termasuk dalam golongan antibodi PD-1 serta atezolizumab yang masuk dalam golongan antibodi PD-L1.Kata kunci: morfologi adenokarsinoma paru; patogenesis; imunoterapi

Gambaran Self Directed Learning Readiness (SDLR) pada Mahasiswa Tingkat Pertama Program Studi Pendidikan Dokter di Fakultas Kedokteran Universitas Sam Ratulangi Mandolang, Arselina C.
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.33772

Abstract: The concept of self-directed learning (SDL) develops rapidly in distance education. This independent learning can be assessed by measuring the score of self-directed learning readiness (SDLR). The Medical Undergraduate Program of Faculty of Medicine Sam Ratulangi University uses the problem based learning (PBL) method which requires students to be able to study independently. The SDLR score of students is very important in the first year of study, therefore, the students will be evaluated by the institution immediately, as well as encouraging them to adapt the independent learning method. This study was aimed to obtain the description of SDLR score in the first-year students of Medical Undergraduate Program of Faculty of Medicine, Sam Ratulangi University. This was a descriptive study with a cross sectional design. The study was conducted on the first year students by using the SDLR questionnaire of Fisher modified by Nyambe.Â The results showed that a total of 109 students (69.87%) had high SDLR score, 44 students (28.2%) had moderate score, and three students (1.92%) had low score. In conclusion, most of the first year students of Medical Undergraduate Program Faculty of Medicine, Sam Ratulangi University had high SDLR scores.Keywords: self directed learning readiness (SDLR); medical educationÂ Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Abstrak: Konsep belajar mandiri atau self directed learning (SDL) berkembang pesat pada pendidikan jarak jauh. Pembelajaran mandiri ini dapat dinilai dengan mengukur skor self directed learning readiness (SDLR). Program Studi Pendidikan Dokter (PSPD) Fakultas Kedokteran Universitas Sam Ratulangi menggunakan metode problem based learning (PBL) yang menuntut mahasiswa untuk dapat belajar mandiri. Skor SDLR dari mahasiswa sangat penting pada tahun pertama pendidikan agar dapat segera dievaluasi oleh institusi dan untuk mendorong mahasiswa agar dapat menyesuaikan dengan metode belajar mandiri.Â Penelitian ini bertujuan untuk mengetahui gambaran SDLR pada mahasiswa tingkat pertama Program Studi Pendidikan Dokter (PSPD) di Fakultas Kedokteran Universitas Sam Ratulangi.Â Jenis penelitian ialah deskritif dengan desain potong lintang. Penelitian ini dilakukan pada mahasiswa tingkat pertama dengan meng-gunakan kuesioner SDLR dari Fisher yang dimodifikasi oleh Nyambe. Hasil penelitian mendapat-kan 109 mahasiswa (69,87%) mempunyai skor SDLR tinggi, 44 mahasiswa (28,2%) dengan skor sedang, dan 3 mahasiswa (1,92%) skor rendah.Â Simpulan penelitian ini ialah sebagian besar mahasiswa tingkat pertama PSPD Fakultas Kedokteran Universitas Sam Ratulangi mempunyai skor SDLR tinggi.Kata kunci: self directed learning readiness (SDLR); pendidikan kedokteran

Rehabilitasi Medik pada Pasien Coronavirus Disease 2019 Parauba, Mercy C. K.; Gessal, Joudy; Lampah, Christopher
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.33780

Abstract: COVID-19 could cause respiratory, physical and psychological dysfunctions. These dysfunctions reduce the patient's functional capacity ultimately. Changes in physical function over a period of hospitalizations and critical illness are more common occurr in patients with more severe or pre-existing disease comorbidities which often lead to mobility disabilities and restrictions in activities of daily life. Physical medicine and medical rehabilitation play an impor-tant role in increasing the functional capacity of COVID-19 patients. This study was aimed to eva-luate the rehabilitation of COVID-19 patients. This was a literature review study using databases of Clinical Key, Web of Science, Pub Med, and Google Schoolar. The keywords used were rehabilitation COVID-19 OR rehabilitation SARS-CoV-2. Based on inclusion and exclusion criteria, eight literatures were selected. The result showed that early rehabilitation should be grant-ed to inpatients with COVID-19. Patients with restricted mobility due to quarantine or lockdown should receive exercise programs to reduce the risk of frailty, sarcopenia, cognitive decline, and depression. Telerehabilitation may represent the first option for individuals at home. In conclusion, proper rehabilitation can reduce the consequences of decreasing functional capacity.Keywords: rehabilitation; COVID-19 patientsÂ Abstrak; COVID-19 dapat menyebabkan disfungsi pernapasan, fisik, dan psikologis yang menurunkan kapasitas fungsional pasien. Perubahan fungsi fisik selama periode rawat inap dan penyakit kritis lebih umum dialami oleh pasien dengan penyakit COVID-19 yang lebih parah atau disertai komorbiditas dan dapat berakibat cacat mobilitas dan pembatasan dalam aktivitas kehi-dupan sehari-hari. Kedokteran fisik dan rehabilitasi medik memiliki peran penting dalam mening-katkan kapasitas fungsional pasien COVID-19. Penelitian ini bertujuan untuk mengetahui peran rehabilitasi medik pada pasien COVID-19. Jenis penelitian ialah literature review menggunakan database Clinical Key, Web of Science, PubMed, dan Google Scholar. Kata kunci yang digunakan yaitu rehabilitasi COVID-19 OR rehabilitasi SARS-CoV-2. Seleksi data berdasarkan kriteria inklusi dan ekslusi mendapatkan delapan literatur. Hasil penelitian menunjukkan bahwa rehabilitasi dini harus diberikan kepada pasien rawat inap dengan COVID-19. Pasien dengan mobilitas terbatas karena karantina atau lockdown harus menerima latihan program untuk mengurangi risiko kelemahan, sarkopenia, penurunan kognitif, dan depresi. Telerehabilitasi mungkin merupakan pilihan pertama bagi individu di rumah. Simpulan penelitian ini ialah rehabilitasi dini yang tepat dapat mengurangi konsekuensi penurunan kapasitas fungsional.Kata kunci: rehabilitasi; pasien COVID-19

St. Georgeâ€™s Respiratory Questionnaire (SGRQ) sebagai Alat Bantu Diagnostik serta Prediktor Terjadinya Chronic Pulmonary Aspergillosis (CPA) pada Pasien Tuberkulosis Paru Pasca Terapi Wangko, William S.; Kurniawan, Indra; Wongkar, Maarthen C. P.; Nugroho, Agung; Polii, Efata B
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.32890

Abstract: Patients of post therapy lung tuberculosis (TB) that still have permanent or worsened clinical signs might be caused by chronic pulmonary aspergillosis (CPA). Diagnosis of CPA is difficult to confirmed without complete supporting tests. This study was aimed to establish whether Saint Georgeâ€™s Respiratory Questionnaire (SGRQ) could be used as diagnostic tool and predictor of the occurence of CPA in post therapy lung TB patients. This was an analytical observational study with a cross sectional design. There were 72 patients who had negative Gene Xpert sputum; 34.7% with positive Aspergillus-specific IgG. Their clinical signs were evaluated with SGRQ. The results showed that there was a very significant relationship between clinical score and CPA (p<0.0001). The lower the clinical score the less the probability of CPA. In this analysis we determined the diagnosis value of clinical score with a probability cut-off point = 0.5 which led to clinical score cut-off point of 45.6 with further results, as follows: sensitivity 68.0%; specificity 95.7%; positive predictive value 89.5%; negative predictive value 84.9%; OR 47.8, and CI 95% (9,2-248,2). In conclusion, SGRQ could be used as diagnostic tool and predictor of the occurence of CPA in post therapy lung TB patients.Keywords: post therapy lung TB; chronic pulmonary aspergillosis; Saint Georgeâ€™s Respiratory Questionnaire (SGRQ)Â Â Abstrak: Pasien TB paru pasca terapi yang masih memperlihatkan gejala klinis menetap atau bahkan memberat dapat disebabkkan oleh adanya chronic pulmonary aspergillosis (CPA). Diagnosis CPA sulit ditegakkan tanpa adanya pemeriksaan penunjang yang lengkap. Penelitian ini bertujuan untuk menentukan apakah Saint Georgeâ€™s Respiratory Questionnaire (SGRQ) dapat menjadi alat bantu diagnostik serta prediktor terjadinya CPA pada pasien TB paru pasca terapi. Jenis penelitian ialah analitik observasional dengan desain potong lintang. Hasil penelitian mendapatkan 72 pasien dengan sputum Gene Xpert negatif (34,7% dengan positif IgG Aspergillus) dilakukan penilaian skor klinis menggunakan SGRQ. Hasil uji menunjukkan terdapat hubungan sangat bermakna antara skor klinis dengan terjadinya CPA (p<0,0001). Makin rendah skor klinis makin kecil peluang terjadinya CPA. Melalui analisis ini dapat ditentukan nilai diagnosis skor klinis SGRQ dengan mengambil titik potong peluang = 0,5. Nilai peluang = 0,5 memberikan titik potong skor klinis = 45,6.Â Dengan titik potong skor klinis SGRQ = 45,6 diperoleh nilai-nilai diagnosis sebagai berikut: Sensitivitas = 68,0%; Spesifisitas = 95,7%; Nilai Prediksi Positif = 89,5%; Nilai Prediksi Negatif = 84,9%; OR = 47,8 dengan CI 95% (9,2-248,2). Simpulan penelitian ini ialah SGRQ dapat menjadi alat bantu diagnostik serta prediktor terjadinya CPA pada pasien TB paru pasca terapi.Kata kunci: tuberkulosis paru pasca terapi;Â chronic pulmonary aspergillosis;Â Saint Georgeâ€™s Respiratory Questionnaire (SGRQ)

Efek Hepatotoksisitas Tanaman Obat Fatti, Vally T. T.; Lintong, Poppy M.; Sambuaga, Maria K.
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.33545

Abstract: The utilization of medicinal plants in Indonesia has been going on for generations even before modern medicine began to be marketed. Although its properties are widely known, but certain medicinal plants can give toxic effects to the liver. This study was aimed to re-evaluate the hepatotoxic effects of medicinal plants and changes in liver morphology. This was a literature review study using databases of Pubmed, ClinicalKey, and Google Scholar. The results obtained five medicinal plants that had hepatotoxic effects. Areca catechu showed morphological changes in the form of hemorrhagic, sinusoid dilation, lobular inflammation, lobular disarray, necrosis, interface hepatitis, microsteatosis, hepatocellular cholestasis, and steatosis. Myrmecodia pendans showed the presence of fat degeneration, necrosis, and inflammatory cell infiltration. Annona muricata indicated the presence of hepatocyte swelling. Gynura divaricata showed increases of SGOT and SGPT levels. Vernonia amygdalina Del showed the presence of cellular degeneration and necrosis of hepatocytes. In conclusion, the most diverse morphological changes of liver are caused by Areca catechu along with large dose consumption meanwhile the most minimal morphological changes of the liver are caused by Annona muricata.Keywords: herbal medicine; hepatotoxic effectÂ Â Abstrak: Pemanfaatan tanaman obat di Indonesia telah berlangsung selama turun-temurun bahkan sebelum obat modern mulai dipasarkan. Meskipun khasiatnya telah banyak diketahui, namun tanaman obat tertentu dapat memberikan efek toksik pada hati. Penelitian ini bertujuan untuk mengevaluasi kembali efek hepatotoksik tanaman obat dan perubahan morfologik hati. Jenis penelitian ialah literature review, menggunakan database Pubmed, ClinicalKey, dan Google Scholar. Hasil penelitian ini mendapatkan lima jenis tanaman obat yang bersifat hepatotoksik. Areca catechu menunjukkan adanya perubahan morfologik berupa perdarahan, dilatasi sinusoid, inflamasi lobular, lobular disarray, nekrosis, interface hepatitis, mikrosteatosis, kolestasis hepatoseluler, dan steatosis. Myrmecodia pendans menunjukkan adanya degenerasi lemak, nekrosis, dan infiltrasi sel radang. Annona muricata menunjukkan adanya pembengkakan hepatosit. Gynura divaricata menunjukkan adanya peningkatan kadar SGOT dan SGPT. Vernonia amygdalina Del menunjukkan adanya degenerasi dan nekrosis hepatosit. Simpulan penelitian ini ialah perubahan morfologik hati yang paling beragam disebabkan oleh Areca catechu seiring dengan besar dosis yang dikonsumsi sedangkan perubahan morfologik hati yang paling minimal disebabkan oleh Annona muricata.Kata kunci: tanaman obat; efek hepatotoksik

Acute Kidney Injury in Critically Ill Patients Setyawan, Yuswanto
Medical Scope Journal Vol 3, No 1 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.3.1.2021.32694

Abstrak: Gagal ginjal akut (GGA) sering ditemukan dalam praktek klinik namun diagnosisnya dapat tertunda oleh karena keterbatasan alat diagnostik. Dewasa ini, kriteria diagnostik RIFLE, AKIN, dan KDIGO untuk menilai adanya GGA dan keparahannya dianggap tidak cukup untuk menggambarkan kompleksitas sindrom GGA. Proteinuria dan mikroalbuminuria yang merupa-kan marker klasik progresi cedera ginjal kronik, telah dipergunakan dan divalidasi untuk progresi GGA ke CKD. Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), dan urinary cystatin C dapat berperan dalam memrediksi pemulihan ginjal. Indikasi biopsi ginjal pada pasien kritis ialah gangguan ginjal yang tidak jelas atau progresi CKD dengan hematuria glomerulus dan proteinuria lebih dari 1 gram per hari, manifestasi ginjal dari penyakit sistemik yang mengancam nyawa, kecurigaan penolakan akut atau kronik dari ginjal transplan. Mempertahankan hemodinamik yang adekuat seharusnya bermanfaat dalam pence-gahan onset atau perburukan GGA, namun kelebihan cairan harus dihindari. Sampau saat ini penentuan saat inisiasi acute renal replacement therapy (ARRT) masih kontroversial, demikian pula nilai ambang spesifik untuk memulainya belum sepenuhnya disepakati. Kata kunci: gagal ginjal akut; penyakit kritis' laju filtrasi glomerulus (LFG)Â Â Abstract: Acute kidney injury (AKI) is a common problem in clinical practice, but its diagnosis could be delayed due to the inherent limitation of current diagnostic tools. Current practice suggests that RIFLE, AKIN, and KDIGO diagnostic criteria used to assess the presence of AKI and its severity are insufficient to illustrate the complexity of the AKI syndrome. Proteinuria and micro-albuminuria, classical markers of chronic kidney disease (CKD) progression, have been used and validated for the progression of AKI to CKD. Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and urinary cystatin C could play a role in prediction of renal recovery. Indication of renal biopsy in critically ill patients are unexplained renal impairment or progression of CKD with both glomerular hematuria and proteinuria more than 1 gr per day, renal manifestations of life threathening systemic disease, suspected acute or chronic rejection of a transplanted kidney. The maintenance of adequate hemodynamics should be beneficial in preventing the onset or the worsening of AKI, but fluid overload should be avoided. Timing of acute renal replacement therapy (ARRT) initiation is still controversial, moreover, specific thresholds for starting are still unclear.Keywords: acute kidney injury (AKI); critically ill; glomerular filtration rate (GFR)

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Sunny Wangko

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sunnypatriciawangko@gmail.com

Editorial Address
medscopej@gmail.com

Location
Kota manado,

Sulawesi utara

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Abstract

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Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Sunny Wangko

Contact Email sunnypatriciawangko@gmail.com

Phone +628124455733

Journal Mail Official sunnypatriciawangko@gmail.com

Editorial Address medscopej@gmail.com

Location Kota manado, Sulawesi utara INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Sunny Wangko

Contact Email
sunnypatriciawangko@gmail.com

Phone
+628124455733

Journal Mail Official
sunnypatriciawangko@gmail.com

Editorial Address
medscopej@gmail.com

Location
Kota manado,

Sulawesi utara

INDONESIA